Monday, April 22, 2013

Chad Mendes and Myles Jury among the six UFC on Fox 7 fighters scoring knockouts on prelims

UFC on Fox 7 started out with a knockout, followed by a knockout and then a knockout. Before fans at the fights in San Jose had eaten lunch, the competition was already fierce for the Knockout of the Night.

It started with Yoel Romero, an Olympic wrestler who knocked out Clifford Starks with a flying knee 1:32 in the first round.

Anthony Njokuani followed Romero's knockout with a pasting of Roger Bowling. Njokuani ruined Bowling's UFC debut with a second-round KO.

T.J. Dillashaw kept the KO-party going with a knockout of Hugo Viana at 4:22 of the first round. Jorge Masvidal won a bloody technical decision over Tim Means and then the knockout fun started all over again.

Joseph Benavidez dominated Darren Uyenoyama for two rounds, then finished up with a TKO with just 10 seconds left in the second round.

Myles Jury stayed undefeated with a knockout of Ramsey Nijem at 1:02 in the second round. Francis Carmont and Lorenz Larkin broke the KO streak with a decision. The judges saw it 29-28 on all three cards for Carmont, thought Larkin controlled the bout and had stellar takedown defense.

Chad Mendes finished off the knockout-filled preliminary card with a KO of Darren Elkins in 1:08. It's his third straight win since losing to Jose Aldo in his first title shot. After the fight, he asked for another one.

What did you think of the prelims? Speak up on Facebook or in the comments. Get in the fight night conversation by following Cagewriter on Twitter.

Other popular content on Yahoo! Sports:
? Images from the manhunt, capture of Boston bombing suspect
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? David Ortiz punctuates Red Sox pregame with strong statement

Source: http://sports.yahoo.com/blogs/mma-cagewriter/chad-mendes-myles-jury-among-six-ufc-fox-000141669--mma.html

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Sunday, April 21, 2013

Texas fertilizer company didn't heed disclosure rules

By Joshua Schneyer, Ryan McNeill and Janet Roberts

NEW YORK (Reuters) - The fertilizer plant that exploded on Wednesday, obliterating part of a small Texas town and killing at least 14 people, had last year been storing 1,350 times the amount of ammonium nitrate that would normally trigger safety oversight by the U.S. Department of Homeland Security (DHS).

Yet a person familiar with DHS operations said the company that owns the plant, West Fertilizer, did not tell the agency about the potentially explosive fertilizer as it is required to do, leaving one of the principal regulators of ammonium nitrate - which can also be used in bomb making - unaware of any danger there.

Fertilizer plants and depots must report to the DHS when they hold 400 lb (180 kg) or more of the substance. Filings this year with the Texas Department of State Health Services, which weren't shared with DHS, show the plant had 270 tons of it on hand last year.

A U.S. congressman and several safety experts called into question on Friday whether incomplete disclosure or regulatory gridlock may have contributed to the disaster.

"It seems this manufacturer was willfully off the grid," Rep. Bennie Thompson, (D-MS), ranking member of the House Committee on Homeland Security, said in a statement. "This facility was known to have chemicals well above the threshold amount to be regulated under the Chemical Facility Anti-Terrorism Standards Act (CFATS), yet we understand that DHS did not even know the plant existed until it blew up."

Company officials did not return repeated calls seeking comment on its handling of chemicals and reporting practices. Late on Friday, plant owner Donald Adair released a general statement expressing sorrow over the incident but saying West Fertilizer would have little further comment while it cooperated with investigators to try to determine what happened.

"This tragedy will continue to hurt deeply for generations to come," Adair said in the statement.

Failure to report significant volumes of hazardous chemicals at a site can lead the DHS to fine or shut down fertilizer operations, a person familiar with the agency's monitoring regime said. Though the DHS has the authority to carry out spot inspections at facilities, it has a small budget for that and only a "small number" of field auditors, the person said.

Firms are responsible for self reporting the volumes of ammonium nitrate and other volatile chemicals they hold to the DHS, which then helps measure plant risks and devise security and safety plans based on them.

Since the agency never received any so-called top-screen report from West Fertilizer, the facility was not regulated or monitored by the DHS under its CFAT standards, largely designed to prevent sabotage of sites and to keep chemicals from falling into criminal hands.

The DHS focuses "specifically on enhancing security to reduce the risk of terrorism at certain high-risk chemical facilities," said agency spokesman Peter Boogaard. "The West Fertilizer Co. facility in West, Texas is not currently regulated under the CFATS program."

The West Fertilizer facility was subject to other reporting, permitting and safety programs, spread across at least seven state and federal agencies, a patchwork of regulation that critics say makes it difficult to ensure thorough oversight.

An expert in chemical safety standards said the two major federal government programs that are supposed to ensure chemical safety in industry - led by the Environmental Protection Agency (EPA) and Occupational Safety and Health Administration (OSHA) - do not regulate the handling or storage of ammonium nitrate. That task falls largely to the DHS and the local and state agencies that oversee emergency planning and response.

More than 4,000 sites nationwide are subject to the DHS program.

"This shows that the enforcement routine has to be more robust, on local, state and federal levels," said the expert, Sam Mannan, director of process safety center at Texas A&M University. "If information is not shared with agencies, which appears to have happened here, then the regulations won't work."

HODGEPODGE OF REGULATION

Chemical safety experts and local officials suspect this week's blast was caused when ammonium nitrate was set ablaze. Authorities suspect the disaster was an industrial accident, but haven't ruled out other possibilities.

The fertilizer is considered safe when stored properly, but can explode at high temperatures and when it reacts with other substances.

"I strongly believe that if the proper safeguards were in place, as are at thousands of (DHS) CFATS-regulated plants across the country, the loss of life and destruction could have been far less extensive," said Rep. Thompson.

A blaze was reported shortly before a massive explosion leveled dozens of homes and blew out an apartment building.

A Ryder truck packed with the substance mixed with fuel oil exploded to raze the Oklahoma federal building in 1995. Another liquid gas fertilizer kept on the West Fertilizer site, anhydrous ammonia, is subject to DHS reporting and can explode under extreme heat.

Wednesday's blast heightens concerns that regulations governing ammonium nitrate and other chemicals - present in at least 6,000 depots and plants in farming states across the country - are insufficient. The facilities serve farmers in rural areas that typically lack stringent land zoning controls, many of the facilities sit near residential areas.

Apart from the DHS, the West Fertilizer site was subject to a hodgepodge of regulation by the EPA, OSHA, the U.S. Department of Transportation, the Texas Department of State Health Services, the Texas Commission on Environmental Quality and the Office of the Texas State Chemist.

But the material is exempt from some mainstays of U.S. chemicals safety programs. For instance, the EPA's Risk Management Program (RMP) requires companies to submit plans describing their handling and storage of certain hazardous chemicals. Ammonium nitrate is not among the chemicals that must be reported.

In its RMP filings, West Fertilizer reported on its storage of anhydrous ammonia and said that it did not expect a fire or explosion to affect the facility, even in a worst-case scenario. And it had not installed safeguards such as blast walls around the plant.

A separate EPA program, known as Tier II, requires reporting of ammonium nitrate and other hazardous chemicals stored above certain quantities. Tier II reports are submitted to local fire departments and emergency planning and response groups to help them plan for and respond to chemical disasters. In Texas, the reports are collected by the Department of State Health Services. Over the last seven years, according to reports West Fertilizer filed, 2012 was the only time the company stored ammonium nitrate at the facility.

It reported having 270 tons on site.

"That's just a god awful amount of ammonium nitrate," said Bryan Haywood, the owner of a hazardous chemical consulting firm in Milford, Ohio. "If they were doing that, I would hope they would have gotten outside help."

In response to a request from Reuters, Haywood, who has been a safety engineer for 17 years, reviewed West Fertilizer's Tier II sheets from the last six years. He said he found several items that should have triggered the attention of local emergency planning authorities - most notably the sudden appearance of a large amount of ammonium nitrate in 2012.

"As a former HAZMAT coordinator, that would have been a red flag for me," said Haywood, referring to hazardous materials.

(This story corrects rental truck brand used by McVeigh was from Ryder, not U-Haul, in paragraph 20 in April 20 story)

(Additional reporting by Anna Driver in Houston, Timothy Gardner and Ayesha Rascoe in Washington, and Selam Gebrekidan and Michael Pell in New York; Editing by Mary Milliken and Robert Birsel)

Source: http://news.yahoo.com/texas-fertilizer-company-didnt-heed-disclosure-rules-blast-171654800--finance.html

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Do You Still Buy Vinyl?

Today is Record Store Day, complete with a slew of special releases on everybody's favorite antiquated audio medium. Hobbyists everywhere rushed out this morning to stand in line in front of local shops to pick up a couple of the good old-fashioned discs. How about you? More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/CuVwcXSpPuM/do-you-still-buy-vinyl

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[NSFW] Android adult app store MiKandi bares even more (and does it better) in Version 4

MiKandi

New UI, more content and faster performance all come to one of Android's premier adult apps

MiKandi -- one of the earlier adult app stores for Android -- this week was updated to Version 4, bringing with it a new user interface, improved performance, and more of that old fashion adult fun that doesn't quite fit on Google Play. 

Jen McEwen, MiKandi's chief marketing officer, tell us that new look bares more than ever before. "MiKandi is the Las Vegas of app stores," McEwen told Android Central by e-mail. "It’s a fun, sexy playground for adults. With MiKandi V4, we take full advantage of the limited space on every device by displaying more than twice as much content than previous versions. Now browsing and discovering adult apps is like walking down the Las Vegas Strip. Everywhere you turn is a visual feast."

read more

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/IbeB8jEDjgg/story01.htm

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Scroll Marker Helps Keep Your Place on Long Web Pages

Chrome: If you're reading a long article on a computer screen, it can be easy to lose your place while scrolling. Scroll Marker draws a small line at the bottom of your screen to keep your eyes in the right place while you move down the page.

This is basically the digital equivalent of using a bookmark or your finger to keep track of your position on a printed page. When you enable the extension, it will draw a thin line across the bottom of your browser. When you scroll, it will move with the content and remain in place for a few moments to keep you from losing your spot. For such a simple app, Scroll Marker comes with lots of customization options. You can change the size and color of the line, how far it's offset from the bottom of the browser window, and how long it stays in place after you scroll.

This is something you'll probably keep disabled most of the time, but it's helpful if you're on a page without much formatting that doesn't give you a lot of visual anchors, or if you're the kind of person that has to keep a finger on the page.

Scroll Marker (Free) | Chrome Web Store via AddictiveTips

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/glbmr4UvO3g/scroll-marker-helps-keep-your-place-on-long-web-pages-476390294

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After shipwreck, Costa Concordia gets the musical treatment

The 2012 Costa Concordia cruise ship sinking is the loose inspiration for a new Bollywood-style musical to be filmed in Italy this summer.

By Nick Squires,?Correspondent / April 17, 2013

The luxury cruise ship Costa Concordia leans on its side after running aground in the tiny Tuscan island of Giglio, Italy, Jan. 2012.

Gregorio Borgia/AP/File

Enlarge

It was one of the most dramatic maritime disasters in modern times, but the Costa Concordia tragedy has now inspired a Bollywood-style musical.

Skip to next paragraph Nick Squires

Italy Correspondent

Nick Squires has been?based in Rome since 2008, from which he covers Italy, the Vatican, and surrounding countries, from Greece to the Balkans. Educated at Oxford University, he spent two years working at a newspaper in Hong Kong before joining the BBC World Service in London. He then spent eight years based in Sydney, from where he covered Australia and traveled on assignments to the South Pacific, East Timor, and Papua New Guinea.

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In an initiative that may seem insensitive to some, an Indian film company will start shooting the movie in Italy over the next few weeks.

The film has no name yet, but it will be loosely based on the plight of the Costa Concordia, the luxury cruise ship which partially sank after ploughing into rocks off the tiny island of Giglio in January 2012.

Thirty-two people lost their lives in the accident, including a 5-year-old girl.

Basing an all-singing, all-dancing film on the tragedy may see ghoulish, but those behind the movie insist it will be done tastefully.

?It will be only loosely based on the sinking of the Costa Concordia,"?says Stefania Ippoliti of the Tuscan Film Commission, which is helping with the project.?"It?s about a group of people who are stranded on an island after a shipwreck.?It will be very light in tone, nothing like the actual disaster. It?s going to be a romantic comedy, not a tragedy.?

Location scouts are expected to arrive soon, with filming to start at the end of May or in early June.

It will be filmed somewhere in the Tuscan archipelago of islands ? not on Giglio itself, because of local sensitivities and the fact that the island has in effect become a giant naval shipyard, as a multi-national team of engineers works to refloat the wreck of the Concordia and tow it off to be scrapped on the Italian mainland.

Location scouts will instead look at some of the other islands in the archipelago ? possibly nearby Elba, where Napoleon was sent into exile, or tiny Capraia and Pianosa.

The film is to be made by?Sri Mishri Productions, a company based in Chennai in the southern Indian province of Tamil Nadu.

It won?t in fact, be a ?Bollywood? movie because that denotes movies made in Hindi by the film industry based in Mumbai, the city once known as Bombay.

Instead?it is part of a Tamil language genre of movies known as ?Kollywood," a nickname that combines Hollywood and Kodambakkam, a neighborhood in Chennai.

Perhaps surprisingly, the concept of Kollywood-meets-the-Concordia has been welcomed by at least one survivor.

Benji Smith, an American who was on his honeymoon on the Concordia when it went down, thinks it is a ?wonderful? idea.

?As long as the story is told well, I think each storyteller should choose the narrative structure and medium that communicates most clearly with their audience,? he says.

Mr. Smith, a computer scientist from Boston, is himself a storyteller ? he wrote a book about the sinking of the cruise liner in which he described how he and his new wife, classical musician Emily Lau, thought they were going to die on the night of the accident.

The book, "Abandoned Ship: An Intimate Account of the Costa Concordia Shipwreck," was self-published in January, just days before the one-year anniversary of the tragedy.

Preliminary hearings are currently taking place in a court in Grosseto, Tuscany, for the former captain of the ship, Francesco Schettino, who is expected to be sent to trial on charges of abandoning ship and manslaughter.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/VEQIBX_16VU/After-shipwreck-Costa-Concordia-gets-the-musical-treatment

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Saturday, April 20, 2013

Muscle repair after injury helped by fat-forming cells

Apr. 19, 2013 ? UC San Francisco scientists have discovered that muscle repair requires the action of two types of cells better known for causing inflammation and forming fat.

The finding in mice, published in the April 11 issue of Cell, showed that a well-known immune cell called the eosinophil [ee-oh-SIN-oh-fil] carries out the beneficial role in two ways -- by clearing out cellular debris from damaged tissue and teaming up with a type of cell that can make fat to instead trigger muscle regrowth.

The study, led by Ajay Chawla, MD, PhD, an associate professor of medicine at the UCSF Cardiovascular Research Institute, showed that after eosinophils move to the site of injury, they collaborate with a kind of progenitor cell -- immature cells similar to stem cells -- to drive the formation of new muscle fibers. The progenitors, called the fibro/adipogenic cells (FAP), do not spin off muscle cells directly.

"Without eosinophils you cannot regenerate muscle," Chawla said.

FAP cells have been known for their role in making fat, which occurs as the body ages or experiences prolonged immobility. They also have been known to make cells that form connective tissue. But the UCSF study showed that FAP cells also team up with eosinophils to make injured muscles get stronger rather than fatter, at least in mice.

In a kind of cellular chain reaction, Chawla's team found that when eosinophils at the site of muscle injury secrete a molecule called IL-4, FAP cells respond by expanding their numbers. And instead of becoming fat cells, they act on the true muscle stem cells to trigger the regrowth of muscle fibers.

"They wake up the cells in muscle that divide and form muscle fibers," he said.

Eosinophils help fight bacteria and parasites, as do other immune cells, but eosinophils are more often thought of for their maladaptive roles in allergies and other inflammatory reactions. Eosinophils comprise only a few percent of immune cells.

Chawla's team found that, even before active muscle repair, the chain reaction initiated by eosinophils performs another necessary task -- taking out the garbage.

"Eosinophils, acting via FAPs, are needed for the rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues," Chawla said.

Bigger and more abundant immune cells called macrophages -- with large appetites and a propensity to gobble up debris in other destructive scenarios -- had often, but erroneously, been credited with cleaning up messes within distressed muscle tissue.

"Bites from venomous animals, many toxicants, and parasitic worms all trigger somewhat similar immune responses that cause injury," Chawla said. "We want to know if eosinophils and FAPs are universally employed in these situations as a way to get rid of debris without triggering severe reactions such as anaphylactic shock."

Additional UCSF co-authors include postdoctoral fellow Jose E. Heredia, PhD; specialist Lata Mukundan, PhD; technician Francis Chen; Rahul Deo, MD, PhD, an assistant professor of medicine in residence; and Richard M. Locksley, MD, an immunologist and professor of medicine. Stanford researchers Thomas Rando, MD, PhD, and graduate student Alisa Mueller also were members of the study team.

The National Institutes for Health and the California Institute for Regenerative Medicine funded the research.

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Story Source:

The above story is reprinted from materials provided by University of California - San Francisco. The original article was written by Jeffrey Norris.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jose?E. Heredia, Lata Mukundan, Francis?M. Chen, Alisa?A. Mueller, Rahul?C. Deo, Richard?M. Locksley, Thomas?A. Rando, Ajay Chawla. Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration. Cell, 2013; 153 (2): 376 DOI: 10.1016/j.cell.2013.02.053

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/dLKOFclSb0E/130419171649.htm

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Friday, April 19, 2013

Self-Defense ? Why Tasers Are So Effective | Jackie's Women's ...

Related eBooks

The top reason why a taser is the best nonlethal alternative is: a near 100% takedown rate. The civilian versions of the taser do exactly the same things as the law enforcement models do with less options and a shorter range of only 15 feet. Read on to learn more.

Source:Self-Defense ? Why Tasers Are So Effective

Related Reading:

Stick Fighting: Techniques of  Self-DefenseStick Fighting: Techniques of Self-DefenseStep-by-step instructions and over 300 photographs allow the trainee to follow and learn the techniques with ease.

The ideal weapon for self-defense is a stick. To find a comprehensive system of techniques using the stick, we must turn to the East, for systems known to the West have fallen into disuse. In this book, the techniques of Kukishin Ryu-an ancient Japanese method-have been updated and adapted for use today. A thorough grounding in the fundamentals dealt with here will enable you to disarm and control any assailant.

CONTENTS
Section 1: Basic Movements
Section 2: Techniques against First Attack
Section 3: Techniques against Foot Attacks
Section 4: Techniques against Wrist Holding
Section 5: Techniques against Sleeve and Lapel Holding
Section 6: Techniques against Seizure from Behind
Section 7: Techniques against Stick Holding
Section 8: Immobilizations

Self-Defense (Alex Delaware)Self-Defense (Alex Delaware)Dr. Alex Delaware doesn t see many private patients anymore, but the young woman called Lucy is an exception. So is her dream. Lucy Lowell is referred to Alex by Los Angeles police detective Milo Sturgis. A juror at the agonizing trial of a serial killer, Lucy survived the trauma only to be tormented by a recurring nightmare: a young child in the forest at night, watching a strange and furtive act.

Now Lucy s dream is starting to disrupt her waking life, and Alex is concerned. The power of the dream, its grip on Lucy s emotions, suggests to him that it may be more than a nightmare. It may be the repressed childhood memory of something very real. Something like murder.

Vital Point Strikes: The Art and Science of Striking Vital Targets for Self-defense and Combat SportsVital Point Strikes: The Art and Science of Striking Vital Targets for Self-defense and Combat SportsVital Point Strikes is a guide to pressure point striking for the average martial artist. Sang H. Kim demystifies the lore of vital point striking and shows you realistic applications of vital point strikes for self-defense and combat sports. For those new to the concept of vital points, he begins by examining the Eastern theory of acupoints, meridians and ki (qi) and the Western scientific concepts of the nervous and circulatory systems, pain threshold and pain tolerance, and the relationship between pain and fear. This synthesis of accepted Eastern and Western theories helps the reader understand what makes vital point striking work and why it can be not only useful in fighting, but deadly. Based on this introduction, you ll learn about 202 vital points for use in fighting including the name, point number, location, involved nerves and blood vessels, applicable techniques, sample applications, and potential results for each point. The points are illustrated in detail on an anatomically correct human model, with English, Chinese, and Korean names as well as point numbers for easy reference. In addition to identifying the vital points, Sang H. Kim gives you detailed information about the type of techniques that work for vital point striking including a discussion of fighting zones and ranges, plexus strikes, stance and footwork, bodily weapons, striking directions and angles and dozens of applications for common empty hand, grappling, groundfighting, knife and gun attacks. Based on over thirty years experience in the martial arts and in-depth research, Sang H. Kim has created one of the most complete books available on the art and science of vital point striking.

Tags: self defense

Source: http://www.jackiesbazaar.com/womensinterests/self-defense/self-defense-why-tasers-are-so-effective

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This is the Modem World: Who's driving this thing?

Each week Joshua Fruhlinger contributes This is the Modem World, a column dedicated to exploring the culture of consumer technology.

This is the Modem World Who's driving this thing

I was never a fan of push notifications. The only alerts I wanted to get while my phone was sleeping included calls, texts and super-important reminders. I didn't need to know if someone liked the photo that I shared. I didn't want to be notified if I hadn't played a particular game in a few days. I'd get around to it. I'd find out on my own.

But lately, mobile operating system makers are pushing the push, rallying to turn their home screens into notification centers that cull all your social, entertainment and organizational information to allegedly make our lives easier. And, to be fair, the more information we consume, the more home screens filled with notifications and push messages are beginning to make sense: show me what's up so I don't have to go find it. I get it now.

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Source: http://www.engadget.com/2013/04/18/who-is-driving-this-thing/

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Senate should pass mental health bill after gun defeat: Manchin

By David Lawder

WASHINGTON (Reuters) - The Senate should proceed with a stand-alone bill to improve mental health treatment to help stem gun violence after key parts of President Barack Obama's gun control agenda were defeated, a key senator involved in the effort said on Thursday.

Joe Manchin, the West Virginia Democrat who championed stronger background checks for gun purchases, said revisions to that proposal - and a better sales job - will be needed to give senators space to change their votes without appearing as "flip-floppers."

His proposal with Republican Senator Pat Toomey of Pennsylvania to extend background checks to Internet sales and gun shows on Wednesday fell six votes short of the 60 needed to advance in the 100-seat Senate.

"How do we get to the 68 to 70 votes we should have gotten? That's what we need to work on," Manchin told a breakfast sponsored by the Wall Street Journal.

He did not offer a time frame for offering a new version, adding that the Senate "pretty much is worn out" on the issue.

The Senate also defeated on Wednesday proposals to ban military-style assault weapons and high-capacity ammunition magazines.

But one area in which there is significant support in both parties is the improvement of mental health treatment in schools and efforts to prevent those judged mentally unfit from purchasing guns.

Manchin said Senate leaders should not wait on a mental health bill while they consider what to do next on background check measures.

"After I talked to the teachers in West Virginia, they need it now. If we can do it now, we should do it," Manchin said. "They don't need to wait until we strategize and put a package together that's more solid, in all honesty."

He said he would concentrate mental health treatment improvements and funding at the elementary school level, where behavioral problems can often be identified early by teachers.

Manchin's proposal attempted to limit new requirements for background checks to commercial transactions at gun shows and online, exempting private sales, but he said there was some confusion and misinformation surrounding that plan that was exploited by the National Rifle Association.

He said the NRA portrayed the background checks as a first step in a long-term effort to enact controls that would eventually lead to the registration and confiscation of guns - something he would never allow as a "gun-loving, Second Amendment defender."

Manchin, who will not have to face voters in his mountainous, pro-gun state for nearly six more years after winning re-election in 2012, said he can take any pressure from the NRA because he "must do what is right."

(Reporting by David Lawder; editing by Jackie Frank)

Source: http://news.yahoo.com/senate-pass-mental-health-bill-gun-defeat-manchin-162434637.html

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3 Mass. General researchers among recipients of Clinical Research Achievement awards

3 Mass. General researchers among recipients of Clinical Research Achievement awards [ Back to EurekAlert! ] Public release date: 18-Apr-2013
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Contact: Sue McGreevey
smcgreevey@partners.org
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Massachusetts General Hospital

Top 10 achievement awards presented at annual meeting of Clinical Research Forum

Three projects led by Massachusetts General Hospital (MGH) investigators have been named among the Clinical Research Forum's Top 10 Clinical Research Achievements of 2012. The MGH-led teams are being honored for work to develop a system allowing people with paralysis to control computerized equipment via a small device implanted into their brains, for a clinical trial showing that a combination of two targeted treatment drugs significantly delays the development of treatment resistance in a common form of melanoma, and for a new approach to diagnosing hard-to-find chromosomal abnormalities that can provide critically important information.

"There's never been a moment in the history of biology that's more optimistic for spectacular breakthroughs to happen. However, it will require strategic investments at a most difficult time in our history," said William F. Crowley Jr., MD, founder and past chairman of the Clinical Research Forum and director of the MGH Clinical Research Program. "America is a world leader in biomedical research and if we are to retain that leadership role globally, we have to continue making these national investments." The awards are being presented today at the Clinical Research Forum's annual meeting in Washington, D.C.

MGH award recipients are:

  • Leigh Hochberg, MD, PhD, MGH Neurology, for a Nature paper describing how the investigational BrainGate System developed through a continuing collaboration with colleagues at Brown University and the Veterans Administration Medical Center in Providence allowed two patients with paralysis affecting all four limbs to reach for and grasp objects using robotic arms controlled directly by their brain activity. Both study participants have been paralyzed for several years by brainstem strokes. This work is also receiving the Clinical Research Forum's Herbert Pardes Clinical Research Excellence Award as the most outstanding project nominated for this year's Top 10 Awards. More information on BrainGate is available at http://www.braingate2.org.
  • Keith Flaherty, MD, MGH Cancer Center, for a New England Journal of Medicine paper reporting that combined treatment with two kinase inhibitors dabrafenib and trametinib delayed the development of treatment resistance in metastatic melanoma patients with tumors driven by mutations in the BRAF gene, which accounts for about half the cases of the deadly skin cancer. The phase I/II study, which found that combination treatment delayed resistance about four months longer than treatment with dabrafenib alone, is being followed with a larger phase II trial. A news release describing this study may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1274.
  • Michael Talkowski, PhD, MGH Center for Human Genetic Research, for two papers. The first, published in Cell, identified 33 genes associated with autism and related disorders, 22 for the first time, using a gene-sequencing method that detects the location of abnormalities in which DNA segments are moved within the same chromosome or exchanged with segments in other chromosomes, leaving the overall size of the chromosomes unchanged. A news release describing this paper may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1460. The second paper, published in the New England Journal of Medicine, described use of the sequencing method to accurately determine the genetic basis of a prenatally detected structural abnormality.

Additional award recipients are from Yale University School of Medicine, Columbia University, Johns Hopkins School of Medicine, the University of North Carolina at Chapel Hill, the University of Pennsylvania and the University of Pittsburgh. Awardees were selected from nominated projects by the Clinical Research Forum's Board of Directors, senior leaders at some of the country's top academic health centers, all of whom recused themselves from discussing and judging submissions from their own institutions.

###

The Clinical Research Forum is an organization comprised of the nation's most prestigious and acclaimed academic medical centers and healthcare systems whose goal is to sustain and expand a cadre of talented, well-trained clinical investigators at all stage of career development, and support nurturing environments and comprehensive research capabilities within academic institutions. Its mission is to provide leadership to the national clinical and translational research enterprise and promote understanding and support for clinical research and its impact on health.

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $775 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine. In July 2012, MGH moved into the number one spot on the 2012-13 U.S. News & World Report list of "America's Best Hospitals."


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3 Mass. General researchers among recipients of Clinical Research Achievement awards [ Back to EurekAlert! ] Public release date: 18-Apr-2013
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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Top 10 achievement awards presented at annual meeting of Clinical Research Forum

Three projects led by Massachusetts General Hospital (MGH) investigators have been named among the Clinical Research Forum's Top 10 Clinical Research Achievements of 2012. The MGH-led teams are being honored for work to develop a system allowing people with paralysis to control computerized equipment via a small device implanted into their brains, for a clinical trial showing that a combination of two targeted treatment drugs significantly delays the development of treatment resistance in a common form of melanoma, and for a new approach to diagnosing hard-to-find chromosomal abnormalities that can provide critically important information.

"There's never been a moment in the history of biology that's more optimistic for spectacular breakthroughs to happen. However, it will require strategic investments at a most difficult time in our history," said William F. Crowley Jr., MD, founder and past chairman of the Clinical Research Forum and director of the MGH Clinical Research Program. "America is a world leader in biomedical research and if we are to retain that leadership role globally, we have to continue making these national investments." The awards are being presented today at the Clinical Research Forum's annual meeting in Washington, D.C.

MGH award recipients are:

  • Leigh Hochberg, MD, PhD, MGH Neurology, for a Nature paper describing how the investigational BrainGate System developed through a continuing collaboration with colleagues at Brown University and the Veterans Administration Medical Center in Providence allowed two patients with paralysis affecting all four limbs to reach for and grasp objects using robotic arms controlled directly by their brain activity. Both study participants have been paralyzed for several years by brainstem strokes. This work is also receiving the Clinical Research Forum's Herbert Pardes Clinical Research Excellence Award as the most outstanding project nominated for this year's Top 10 Awards. More information on BrainGate is available at http://www.braingate2.org.
  • Keith Flaherty, MD, MGH Cancer Center, for a New England Journal of Medicine paper reporting that combined treatment with two kinase inhibitors dabrafenib and trametinib delayed the development of treatment resistance in metastatic melanoma patients with tumors driven by mutations in the BRAF gene, which accounts for about half the cases of the deadly skin cancer. The phase I/II study, which found that combination treatment delayed resistance about four months longer than treatment with dabrafenib alone, is being followed with a larger phase II trial. A news release describing this study may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1274.
  • Michael Talkowski, PhD, MGH Center for Human Genetic Research, for two papers. The first, published in Cell, identified 33 genes associated with autism and related disorders, 22 for the first time, using a gene-sequencing method that detects the location of abnormalities in which DNA segments are moved within the same chromosome or exchanged with segments in other chromosomes, leaving the overall size of the chromosomes unchanged. A news release describing this paper may be accessed at http://www.massgeneral.org/about/pressrelease.aspx?id=1460. The second paper, published in the New England Journal of Medicine, described use of the sequencing method to accurately determine the genetic basis of a prenatally detected structural abnormality.

Additional award recipients are from Yale University School of Medicine, Columbia University, Johns Hopkins School of Medicine, the University of North Carolina at Chapel Hill, the University of Pennsylvania and the University of Pittsburgh. Awardees were selected from nominated projects by the Clinical Research Forum's Board of Directors, senior leaders at some of the country's top academic health centers, all of whom recused themselves from discussing and judging submissions from their own institutions.

###

The Clinical Research Forum is an organization comprised of the nation's most prestigious and acclaimed academic medical centers and healthcare systems whose goal is to sustain and expand a cadre of talented, well-trained clinical investigators at all stage of career development, and support nurturing environments and comprehensive research capabilities within academic institutions. Its mission is to provide leadership to the national clinical and translational research enterprise and promote understanding and support for clinical research and its impact on health.

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $775 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine. In July 2012, MGH moved into the number one spot on the 2012-13 U.S. News & World Report list of "America's Best Hospitals."


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Source: http://www.eurekalert.org/pub_releases/2013-04/mgh-tmg041813.php

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Provo, Utah is the third city to get Google Fiber

Provo, Utah is the third city to get Google Fiber

Google Fiber is growing in Kansas City and, as recently reported, coming to Austin, and today Mountain View revealed a third city that will enjoy its high-speed internet: Provo, Utah. The news broke today on the official Fiber blog, Provo's website and the city mayor's personal blog -- what official wouldn't be happy to break that news? If the agreement is approved by the city council, Google will buy the city's existing iProvo network and upgrade it to Gigabit technology. The deal would bring free 5Mbps service to homes already on the iProvo network (for a $30 activation fee) and offer free connectivity for 25 public institutions. The council will vote next Tuesday -- but we can't imagine any verdict other than a resounding "yes."

[Thanks, all]

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Source: Google Fiber blog, Provo Insights

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/xXY50mOqZgg/

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Wednesday, April 17, 2013

Witness who ran toward marathon bomb 'saw bodies flying'

5 hours ago

A Boston couple and an eyewitness who ran toward the scene after two bombs detonated near the finish line at the Boston Marathon on Monday described a chaotic mix of catastrophic injuries and strangers racing to help one another.

Tom Meagher, a finish-line coordinator who ran toward the explosions, detailed a "horrific blast" that almost knocked him to the ground. "I turned and saw a huge wave of smoke and glass coming at me, and I actually saw bodies flying, moving around, uncontrollably."

Doctor who helped victims: People were 'laying in a pile'

Meagher, who has volunteered at the finish line for 17 years, told Matt Lauer on TODAY Tuesday he did not see anything suspicious in the area before the bombs detonated.

Nick Yanni and his wife, Lee-Ann, were injured in the blast. "We were close enough to the bomb that went off by the finish line that there was a lot of bad things going on and everybody was just trying to help everybody,'' Nick Yanni told Lauer.

Boston bombing aftermath: How you can help

The Yannis were standing outside the Marathon Sports store about 10 feet from the finish line, cheering on friends who were running the race. Both were injured when the two bombs detonated: Lee-Ann had emergency surgery for an open fibular fracture after shrapnel ripped through her shin, and is waiting for a skin graft, while Nick sustained a pierced ear drum.

"I'm not sure exactly where (the bomb) was detonated," Lee-Ann said from her hospital bed at Tufts University Medical Center. "It sounded awfully close. We were probably about 10 feet from the finish line. It was quite loud and (you) definitely could smell the smoke and everything when it happened."

The Yannis, who moved to Boston from Orlando in September of last year, were using T-shirts to help stop the bleeding in Lee-Ann's shin. She estimated it took about 15 minutes for her to be carried out, put on a golf cart and taken to a makeshift triage center before she was later taken by ambulance to Tufts University Medical Center. The couple was separated at that time, and Nick went into shock after seeing the extent of her injuries.

'The good outnumber you': Messages of hope for Boston go viral

"When the police came in, they wanted to get anybody who wasn't hurt out so they could take care of anybody who was hurt,'' Nick said.

The bravery of the police and first responders struck a chord with another eyewitness, Stan Ricks, who finished running the marathon only minutes before the first bomb went off. He was in the medical tent when he heard the explosions and quickly left to make room for those injured in the blasts.

"As we?re all trying to get away...the police are running and charging down the street to help,'' Ricks told Natalie Morales. "And a lot of the volunteers went to help. It was truly amazing to see. These guys were really heroes. I was totally impressed.''

Those at the scene are now trying to come to grips with it a day later. Alycia Lane, an anchor at NBC Los Angeles affiliate KNBC, was waiting at a hotel restaurant near the finish line to meet up with a friend who ran in the race when the bombs detonated.

"Everyone was terrified, myself included, not knowing if that was the only bomb, if there were more to come,'' she told TODAY. "This morning it was really about processing about what had taken place. It was just such a terrifying experience. It?s certainly a difficult day.''

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2ac72500/l/0L0Stoday0N0Cnews0Cwitness0Ewho0Eran0Etoward0Emarathon0Ebomb0Esaw0Ebodies0Eflying0E1C9364930A/story01.htm

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Internet Tricks And Tips From Reddit - Business Insider

"On a Google Map page, if you're looking for a specific type of place, (eg: a restaurant), if you type restaurants* (note the star) into the search bar it will find ALL the restaurants within that map window. Or tire shops, cafes, whatever. Using just * will find ALL the businesses in that window."

Source: soulbrothernumbertwo

Source: http://www.businessinsider.com/internet-tricks-and-tips-from-reddit-2013-4?op=1

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Boston explosions: Cities on alert in US and UK

Boston explosions: Los Angeles, New York City, and London have stepped up security in the wake of two explosions near the finish line of the Boston Marathon.

By Tami Abdollah,?Associated Press / April 15, 2013

Medical workers wheel the injured across the finish line during the 2013 Boston Marathon following two explosions in Boston, Monday, April 15, 2013.

(AP Photo/Charles Krupa)

Enlarge

Police in Los Angeles, New York City, London and other cities worldwide stepped up security Monday following explosions at the Boston Marathon.

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Los Angeles police Lt. Andrew Neiman said the department was urging officers to be extra vigilant around large crowds and would increase security at sporting events such as the Los Angeles Dodgers game Monday night.

The department was also activating its emergency operations center to increase communication and increasing patrols for transit and other critical areas, Los Angeles County Sheriff's spokesman Steve Whitmore said.

Police in Washington, San Diego, Vegas and Atlanta were monitoring events closely and assessing potential increases in security measures. Agencies were also stepping up social media response, telling the public via Twitter and Facebook to report suspicious activity to the police.

Chief NYPD spokesman Paul Browne said Monday that critical response teams were deployed around the city, and officials were stepping up security at hotels and other prominent locations.

Police at three major Los Angeles area airports, including Los Angeles International Airport, were in a "heightened state of vigilance," with increased patrols to make it visible that more police were on duty Monday, said Chief of Airport Police Patrick Gannon.

"We have no indications that suggest there's a nexus from Boston to the Los Angeles airport, but in an overabundance of caution, we have heightened our patrols," Gannon said.

British police also said they were reviewing security plans for Sunday's London Marathon. It's the next major international marathon. A London Metropolitan Police spokesman said police are working with marathon officials to review security plans with an eye toward establishing a larger security presence.

On Monday, California emergency management officials activated their statewide threat assessment system, which was established following the Sept. 11, 2001 World Trade Center bombings.

Officials in San Francisco, Los Angeles, Orange County, San Diego and Sacramento were reviewing information from federal authorities for possible threats, said Kelly Huston, assistant secretary of the California Emergency Management System.

In Tennessee, the Nashville Predators will host the Vancouver Canucks on Monday night and hockey fans will see "more visible presence around the building," team spokesman Kevin Wilson said.

Copyright 2013 The Associated Press.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/W2UCy1e5Oik/Boston-explosions-Cities-on-alert-in-US-and-UK

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NASA's Wind mission encounters 'SLAMS' waves

Apr. 16, 2013 ? As Earth moves around the sun, it travels surrounded by a giant bubble created by its own magnetic fields, called the magnetosphere. As the magnetosphere plows through space, it sets up a standing bow wave or bow shock, much like that in front of a moving ship. Just in front of this bow wave lies a complex, turbulent system called the foreshock. Conditions in the foreshock change in response to solar particles streaming in from the sun, moving magnetic fields and a host of waves, some fast, some slow, sweeping through the region.

To tease out what happens at that boundary of the magnetosphere and to better understand how radiation and energy from the sun can cross it and move closer to Earth, NASA launches spacecraft into this region to observe the changing conditions. From 1998 to 2002, NASA's Wind spacecraft traveled through this foreshock region in front of Earth 17 times, providing new information about the physics there.

"I stumbled on some cool squiggles in the data," says Lynn Wilson, who is deputy project scientist for Wind at NASA's Goddard Space Flight Center in Greenbelt, Md. "They turned out to be a special kind of magnetic pulsations called short large amplitude magnetic structures, which we call SLAMS for short."

SLAMS are waves with a single, large peak, a little like giant rogue waves that can develop in the deep ocean. By studying the region around the SLAMS and how they propagate, the Wind data showed SLAMS may provide an improved explanation for what accelerates narrow jets of charged particles back out into space, away from Earth. Tracking how any phenomenon catalyzes the movement of other particles is one of the crucial needs for modeling this region. In this case, understanding just how a wave can help initiate a fast-moving beam might also help explain what causes incredibly powerful rays that travel from other solar systems across interstellar space toward Earth. Wilson and his colleagues published a paper on these results in the Journal of Geophysical Research online on March 6, 2013.

The material pervading this area of space -- indeed all outer space -- is known as plasma. Plasma is much like a gas, but each particle is electrically charged so movement is governed as much by the laws of electromagnetics as it is by the fundamental laws of gravity and motion we more regularly experience on Earth.

"One of the unique things about space weather is how little things can have big effects," says David Sibeck, a space scientist at Goddard who is a co-author on the paper. "An event might seem small and just generate local turbulence, but it can have profound effects downstream. The front of the magnetosphere is right in the line between sun and Earth, so it's a crucial place to understand which small things can lead to big results."

Since the 1970s, researchers have known that particles seem to be reflecting off the magnetosphere, creating intense particle jets called field aligned ion beams, but it's not been clear how. Now, the Wind data helps provide a more detailed snapshot of how they form, as it travels through a slew of SLAMS and the ion beams.

The scientists' job was to map where these events happen in space and time and to try to determine which events initiate which. Wilson says that the solar wind constantly moves toward Earth's bow shock and then reflects off it.

"These structures get excited upstream and they start to grow and steepen, kind of like a water wave," says Wilson. "But instead of breaking and tumbling over, they stand up, getting bigger and faster." He says that the SLAMS attempt to move against the gale of solar wind streaming toward them, but ultimately get pushed back, creating a new messy boundary in front of the magnetosphere. "And then they effectively create their own new bow shock," says Wilson.

Without the SLAMS, one would expect incoming particles from the solar wind to skip and slide along the outside of the bow shock, the way flowing water in a river might move around a large rock. But the SLAMS create a kind of magnetic mirror, causing the solar particles to reflect, attenuating them into one of these field-aligned ion beams, shooting out along magnetic fields back out and away from Earth.

Wind data does not inherently show which of these things create the other, it simply shows the presence of both. However, the ion beams were not seen in the space between the front of the true bow shock and the SLAMS -- only streaming away from the SLAMS out toward space. The beams also only appeared after the SLAMS had a chance to fully form. This strengthened the conclusion that the SLAMS themselves lead to the beams, acting as a magnetic mirror to reflect the particles outward.

The more we know about what happens in the frothy, turbulent area in front of Earth, the more we know about how the solar wind and other material bursting off the sun may be able to penetrate into near Earth-space.

"What happens to Earth's magnetic field depends on what's happening here at the front of the bow shock," says Sibeck. "And what's happening there is dramatic. It's going to affect how much energy moves into the magnetosphere. Once inside the magnetosphere, it can create powerful solar storms and impact communications and GPS satellites that we depend on daily."

The observations also have implications beyond protecting Earth. By sending spacecraft to observe plasma here, scientists can take advantage of the only area of the universe where we can study such plasma movement directly -- and thus apply the research to information about stars across the galaxy as well. For example, astrophysicists would like to better understand what causes cosmic ray acceleration -- particles that are generally much faster than the field aligned ion beams, but accelerated in similar manners, says Wilson. One theory is that a magnetic mirror of some kind causes the particles to bounce back and forth and gain more speed and energy as the mirrors move closer together. Near the front of the magnetosphere, the SLAMS might be doing just that.

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The above story is reprinted from materials provided by NASA/Goddard Space Flight Center.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/22Syc0JxItc/130416180034.htm

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Samsung Galaxy Mega hands-on

DNP Samsung Galaxy Mega handson

When Samsung said it was having a little soiree to celebrate the launch of the Galaxy S 4, we took them on their word. At the end, when they surprised us with the news of something new, for a second we though a Mini might be on the cards... but in fact it was the exact opposite. It turns out, they brought another friend along to the party instead, the recently announced Galaxy Mega. The largest of the two, to be precise. So, while everyone clambered to play with the latest flagship, we thought we'd take some time to get the know the 6.3-inch Galaxy Mega a little better. Want to know if it's phab or slab? Head past the break for our impressions.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uo_WC54ALU8/

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